Everyday a new drug is introduced into the market with manufacturers guaranteeing positive results. This right here is all too uncommon particularly in medicine where laboratory experiments and studies are conducted almost everyday. A new and remarkable form of therapy was discovered for the treatment of diseases caused by an over reactive or abnormal immune system, treatment was given using liposomal clodronate.
The immune system is one of the most important system of the body specifically to one's health. In fact, some people take vitamin supplements to aid their immune system. The stronger it is, the more invincible man becomes. It's all very simple if you think of it, however this may not always be the case sometimes, there are abnormalities in your immune system which causes your cells to attach your own body, hence the term Autoimmune Disease.
There are countless of cells that make up the immune system, macrophages however is said be the core of it. Its primary function is to activate natural immunity and regulate non-phagocytic cells. Macrophages play an important role in natural immune response and immunity, and are responsible in maintaining homeostasis by ingesting and digesting microorganism.
Inflammatory marker as the name implies is a sign that inflammation is currently going on. Famous inflammatory markers includes interleukin 6,8 and 1 as well as TNF-alfa. However, these markers are only a tiny part of the immune system. Indeed, the immune system consists of thousands of cells all of which has its own tiny role.
As a whole, the immune system is a major factor in one's health and body. It does protect one on being infected from common viruses which explains why some people take supplementation to strengthen their immune system. But for some unique reason, the immune system could be the culprit to several medical diseases as well as on transplant rejections.
More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.
To be able to reduce or halt these immune reactions, it will be necessary to suppress the immune system. Although this mode of treatment is not new, not all method of therapy has proved to be quite a success. Transplant rejections are still prominent and disease progression on patients with autoimmune disease is still unpreventable.
With the discovery of clodronic acid therapy, these possibilities may be the least of your concerns. Through the use of liposomes as the drug vehicle the main drug, clodronic acid will be delivered inside the macrophages and after exceeding its threshold, dies by apoptosis. Liposomes are easily engulfed by macrophages which makes it a great choice as a drug vehicle. As the drug is delivered directly into the phagocytic cells, there's a greater chance of suppressing the immune system.
Liposomal clodronate was also discovered to have therapeutic effects in conjunction with anti tumor drugs used in Cancer. Clodronic acid is said to improve the drug absorption of antineoplastic drugs as well as demonstrated the possibility of slowing down cancer growth however, this mode of action is yet to be proved. The combination of decreasing blood vessel density and tumor size shows great promise.
The immune system is one of the most important system of the body specifically to one's health. In fact, some people take vitamin supplements to aid their immune system. The stronger it is, the more invincible man becomes. It's all very simple if you think of it, however this may not always be the case sometimes, there are abnormalities in your immune system which causes your cells to attach your own body, hence the term Autoimmune Disease.
There are countless of cells that make up the immune system, macrophages however is said be the core of it. Its primary function is to activate natural immunity and regulate non-phagocytic cells. Macrophages play an important role in natural immune response and immunity, and are responsible in maintaining homeostasis by ingesting and digesting microorganism.
Inflammatory marker as the name implies is a sign that inflammation is currently going on. Famous inflammatory markers includes interleukin 6,8 and 1 as well as TNF-alfa. However, these markers are only a tiny part of the immune system. Indeed, the immune system consists of thousands of cells all of which has its own tiny role.
As a whole, the immune system is a major factor in one's health and body. It does protect one on being infected from common viruses which explains why some people take supplementation to strengthen their immune system. But for some unique reason, the immune system could be the culprit to several medical diseases as well as on transplant rejections.
More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.
To be able to reduce or halt these immune reactions, it will be necessary to suppress the immune system. Although this mode of treatment is not new, not all method of therapy has proved to be quite a success. Transplant rejections are still prominent and disease progression on patients with autoimmune disease is still unpreventable.
With the discovery of clodronic acid therapy, these possibilities may be the least of your concerns. Through the use of liposomes as the drug vehicle the main drug, clodronic acid will be delivered inside the macrophages and after exceeding its threshold, dies by apoptosis. Liposomes are easily engulfed by macrophages which makes it a great choice as a drug vehicle. As the drug is delivered directly into the phagocytic cells, there's a greater chance of suppressing the immune system.
Liposomal clodronate was also discovered to have therapeutic effects in conjunction with anti tumor drugs used in Cancer. Clodronic acid is said to improve the drug absorption of antineoplastic drugs as well as demonstrated the possibility of slowing down cancer growth however, this mode of action is yet to be proved. The combination of decreasing blood vessel density and tumor size shows great promise.
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