By definition, clodronate liposome is a drug delivered using liposome (a synthetic lipid that encapsulates other substances for ease of administration into the body). Liposome is manly a medium which carries the highly hydrophilic Clodronate thus facilitating its transport into the target organ. Essentially, the aim of this type of drug administration is to achieve higher macrophage depletion after an intravenous injection of the drug.
Like a Trojan horse, liposome carriers clodronate to the target cell where it is ingested by the macrophages. This then releases the drug into the cell and the inhibition of the macrophages activities is achieved by bisphosphonates (the active components in it). Though the idea looks simple, researchers are upbeat that this will be the best cure for most stubborn immune diseases.
Though still in the trial stages, the drug has shown a lot of success and will help in the treatment of cancer, osteoporosis and autoimmune hemolytic anemia. Metastatic carcinoma of the breast and multiple myeloma are among other conditions that the drug will be able to handle. On the other hand, this drug has shown success with the suppression of macrophage activities in neurological disorders, gene therapy and transplantation.
Since other bisphosphonates are in the market, it is easy to predict the side effects that may be associated with the drug once it is released. There is no need to worry though as these effects are classified as mild. For example, a few patients do report stomach pains, nausea and vomiting. In some rare scenarios, bisphosphonates may have some serious reactions.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Additional complications such as unknown malaise, swelling of body parts and mouth pain should also be treated with caution. Physicians in such cases may recommend treatment or drug discontinuation. It is important to note that these are not recorded drug reactions from the drug since it has not been fully put into human use. You should therefore not be discouraged in anyway.
Some general contraindications are common with most prescription drugs. For instance, you should not take the drug if you are allergic to Clodronates or bisphosphonates. Similarly, expecting or breastfeeding mothers should not use the drug. Patients with kidney problems or using other bisphosphonate drugs should not use the drug too. It is also advisable that you stay from these types of drugs if you have inflammation of the gastro intestines.
Clodronate liposome as mentioned before is a prescription drug and thus cannot be shared with a family member, even if they have the same conditions. On the other hand, one cannot use the drugs unless the doctor prescribes it. Once it is officially released, it is expected to bring the much-needed cure for cancer. However, success will depend on how strict the patients will follow the prescription of the doctor.
Like a Trojan horse, liposome carriers clodronate to the target cell where it is ingested by the macrophages. This then releases the drug into the cell and the inhibition of the macrophages activities is achieved by bisphosphonates (the active components in it). Though the idea looks simple, researchers are upbeat that this will be the best cure for most stubborn immune diseases.
Though still in the trial stages, the drug has shown a lot of success and will help in the treatment of cancer, osteoporosis and autoimmune hemolytic anemia. Metastatic carcinoma of the breast and multiple myeloma are among other conditions that the drug will be able to handle. On the other hand, this drug has shown success with the suppression of macrophage activities in neurological disorders, gene therapy and transplantation.
Since other bisphosphonates are in the market, it is easy to predict the side effects that may be associated with the drug once it is released. There is no need to worry though as these effects are classified as mild. For example, a few patients do report stomach pains, nausea and vomiting. In some rare scenarios, bisphosphonates may have some serious reactions.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Additional complications such as unknown malaise, swelling of body parts and mouth pain should also be treated with caution. Physicians in such cases may recommend treatment or drug discontinuation. It is important to note that these are not recorded drug reactions from the drug since it has not been fully put into human use. You should therefore not be discouraged in anyway.
Some general contraindications are common with most prescription drugs. For instance, you should not take the drug if you are allergic to Clodronates or bisphosphonates. Similarly, expecting or breastfeeding mothers should not use the drug. Patients with kidney problems or using other bisphosphonate drugs should not use the drug too. It is also advisable that you stay from these types of drugs if you have inflammation of the gastro intestines.
Clodronate liposome as mentioned before is a prescription drug and thus cannot be shared with a family member, even if they have the same conditions. On the other hand, one cannot use the drugs unless the doctor prescribes it. Once it is officially released, it is expected to bring the much-needed cure for cancer. However, success will depend on how strict the patients will follow the prescription of the doctor.
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