Clodronate Liposome is used in different research laboratories. Clodronate is used as a treatment for different diseases, especially for cancer metastases. It effects further development of metastases, reduces pain and decreases the risk of fractures. Since this drug cannot be delivered to tissues without suppressing macrophage activity, this nano technology is used for this purpose.
To be closed in vivo, this effective compound is delivered encapsulated within liposomes. A liposome is lipid-based tiny particle, designed to carry different compounds in form of suspension. It is lately used in many research laboratories, as highly effective way or delivering drugs to various tissues. In this case, to bones and kidneys.
Manipulating clodronate liposome is associated with some risks, because it is highly irritating to skin, eyes, mucous membranes and respiratory system. It is very important to use appropriate clothing, chemical-resistant goggles and gloves and respirators. This suspension might be dangerous if swallowed or inhaled, and it shouldn't get in contact with your skin or eyes. It can be easily absorbed through skin.
If something like this happens, you need to follow these procedures. If it comes in contact with your eyes, you should wash them for at least fifteen minutes. Skin should be cleaned with soap and plenty of water. You should have respirator to use it if you inhale it, and you should go outside right away. If the person who inhaled it have more serious breathing problems, you should give him an oxygen. If you happen to swallow it, you should call a physician immediately.
Liposomal encapsulated drugs and other compounds are required to manipulate macrophage function. Macrophages have different functions. They participate in natural immune reactions, but they also regulate the function of other, non-phagocytic cells. They ingest and digest microorganisms and macromolecules.
When liposomes encapsulated clodronate gets to tissue, macrophage will ingest and digest it, but they will only destroy this liposome capsule, not the active component. It will be released within this tissue, and then accumulated. Macrophage depleted tissue will allow performing different in vivo researches related to macrophages.
Different diseases can be researched this way, using clodronate liposome. Some autoimmune diseases, transplantation and neurological disorders can also be researched using this type of macrophage suppression. The same method can actually be used for in vitro depletion of macrophages, but it is primarily designed for in vivo researches.
It is important to keep the suspension at appropriate temperature. It shouldn't be exposed to temperatures above 30 degrees of Celsius, or frozen. The ideal storage temperature is four degrees Celsius, and in this case it can be kept one month in refrigerator. For achieving desired results, the suspension should be kept outside the refrigerator until it reaches room temperature, before injecting it to animals.
Always shake the suspension, other ways it won't be homogeneous, and you won't get desired results. If you use the same syringe for different animals, you won't get accurate dosages, and you might infect them. Always shave and cleanse the skin with alcohol before injecting clodronate liposome to your animal.
To be closed in vivo, this effective compound is delivered encapsulated within liposomes. A liposome is lipid-based tiny particle, designed to carry different compounds in form of suspension. It is lately used in many research laboratories, as highly effective way or delivering drugs to various tissues. In this case, to bones and kidneys.
Manipulating clodronate liposome is associated with some risks, because it is highly irritating to skin, eyes, mucous membranes and respiratory system. It is very important to use appropriate clothing, chemical-resistant goggles and gloves and respirators. This suspension might be dangerous if swallowed or inhaled, and it shouldn't get in contact with your skin or eyes. It can be easily absorbed through skin.
If something like this happens, you need to follow these procedures. If it comes in contact with your eyes, you should wash them for at least fifteen minutes. Skin should be cleaned with soap and plenty of water. You should have respirator to use it if you inhale it, and you should go outside right away. If the person who inhaled it have more serious breathing problems, you should give him an oxygen. If you happen to swallow it, you should call a physician immediately.
Liposomal encapsulated drugs and other compounds are required to manipulate macrophage function. Macrophages have different functions. They participate in natural immune reactions, but they also regulate the function of other, non-phagocytic cells. They ingest and digest microorganisms and macromolecules.
When liposomes encapsulated clodronate gets to tissue, macrophage will ingest and digest it, but they will only destroy this liposome capsule, not the active component. It will be released within this tissue, and then accumulated. Macrophage depleted tissue will allow performing different in vivo researches related to macrophages.
Different diseases can be researched this way, using clodronate liposome. Some autoimmune diseases, transplantation and neurological disorders can also be researched using this type of macrophage suppression. The same method can actually be used for in vitro depletion of macrophages, but it is primarily designed for in vivo researches.
It is important to keep the suspension at appropriate temperature. It shouldn't be exposed to temperatures above 30 degrees of Celsius, or frozen. The ideal storage temperature is four degrees Celsius, and in this case it can be kept one month in refrigerator. For achieving desired results, the suspension should be kept outside the refrigerator until it reaches room temperature, before injecting it to animals.
Always shake the suspension, other ways it won't be homogeneous, and you won't get desired results. If you use the same syringe for different animals, you won't get accurate dosages, and you might infect them. Always shave and cleanse the skin with alcohol before injecting clodronate liposome to your animal.
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